ABCC1 and neoplasm: The latter includes generic resistance mechanisms include (i) impaired drug distribution; (ii) survival cues driven by the tumor microenvironment; and (iii) overexpression of multi-drug resistance proteins (e.g. the ATP-binding cassette (ABC) transporters MDR-1, MDR-2 and MRP1 (ABCC1)) which excrete docetaxel into extracellular fluid and decrease the lethal, intracellular concentration of the drug [4].