The observed linkage disequilibrium for the analyzed SNPs, located in TLR4 gene, as well as the significant association of the GC haplotype at those SNPs with the infection, suggested that the simultaneous presence of the G allele at 896 SNP and the C allele at 1196 SNP may have affected the function of TLR4 in the immunity against HCMV in the fetuses and neonates. The gene discussed is TLR4; the disease is infection.