No previous study showed any involvement of TLR9 2848 G>A SNP in HCMV infection, although the polymorphism was reported to be associated with other pregnancy disorders, including the mother-to-child transmission (MTCT) of human immunodeficiency virus type 1 (HIV-1), toxoplasmic retinochoroiditis, as well as cervical cancer [26–30]. The gene discussed is TLR9; the disease is cytomegalovirus infection.