The expression of genes, encoding TLR2 and endosomal TLR3 and TLR9 molecules, as well as scavenger receptor A type 1 (SR-A1), tyrosine-protein kinase Lyn, IL-12 p35 subunit, TIR domain containing adaptor-inducing interferon-beta (TRIF), interferon regulatory factor 3 (IRF-3) and interferon beta (IFN-ß) were observed to be induced after infection of human acute monocytic leukemia cell line THP1 and foreskin fibroblast cell lines with HCMV [17, 18]. The gene discussed is IRF3; the disease is infection.