Inhibiting the function of more than one trophic receptor over-expressed on the exterior surface membrane of neoplastic cell populations is also important because a single immunoglobulin fraction like anti-EGFR, anti-HER2/neu, anti-IGFR, and anti-VEGFR usually are only capable of reducing cancer cell vitality and decreasing rates of proliferation but are generally incapable of evoking cytotoxic resolution of neoplastic disease[15,16,30–34]. This evidence concerns the gene ERBB2 and cancer.