CXCL12 and non-small cell lung carcinoma: Conversely, the SDF-1α/CXCR4 axis-specific inhibitor AMD3100 and CXCR4 knock-down attenuated the pro-invasive effect of radiation and SDF-1α, indicating that SDF-1α/CXCR4 is critical for the radiation-mediated dissemination of NSCLC cells (Figure 9).