Several studies, however, suggest that PARK2 interacts with PINK1, another gene mutated in autosomal recessive familial form of PD (Geisler et al., 2010) to regulate mitochondrial biology, and alters mitochondrial dynamics (Chen and Chan, 2009; Clark et al., 2006; Lee et al., 2004). Here, PRKN is linked to Parkinson disease.