BDNF and neurodegenerative disease: Therefore, the possibility to up-regulate the level of neuroprotective substances, such as NGF, BDNF, and IL-6 is one of the key aspects to improve nervous system development and function, and can be a promising goal in the therapy of neurodegenerative diseases, in which a decreased level of neurotrophins is observed (Lessmann et al. 2003; Aloe et al. 2012; Allen et al. 2013).