Improving both NGF and IL-6 secretion can be important during neonatal development, in control of “adult” neurogenesis in the hippocampus and neocortex and also in the pathogenesis of diseases such as Alzheimer’s disease, Parkinson’s disease, or depression (Bruno et al. 2009; Angelucci et al. 2011). The gene discussed is NGF; the disease is early-onset autosomal dominant Alzheimer disease.