More importantly, drebrin depletion profoundly affects the ability of urothelial cancer cells to grow in anchorage-independency and form tumors in xenograft models suggesting the possibility that drebrin may not only affect progranulin-dependent responses but also regulate additional pathways, which may converge with progranulin signaling thereby promoting bladder tumor initiation and possibly progression. Here, GRN is linked to urinary bladder neoplasm.