ANO1 and cancer: Furthermore, we conducted transwell invasion assays to evaluate the effect of TMEM16A on cancer cell invasion and found that knockdown of TMEM16A significantly (p < 0.05) reduced the ability of AGS cells to invade through the Matrigel matrix and the number of AGS cells from ShTM group that invaded through the Matrigel matrix was significantly decreased as compared with control (Fig. 6C).