Similar findings were seen when STAT3 and NF-kB activation was assessed by immunohistochemistry (Figure 5A and B), which also revealed a reduction of cells positive for p-STAT3 Y705 and p-NF-kB/p65 Ser536 in both transformed epithelial cells and tumor infiltrating cells in the lesions of IL-21 KO-Apcmin/+ mice (Figure 5A and B). Here, STAT3 is linked to neoplasm.