Robust activation of both STAT3 and NF-kB was seen in the neoplastic areas of control mice compared to those derived from IL-21 KO-Apcmin/+ mice, whereas p-STAT3 Y705 and p-NF-kB/p65 Ser536 expression was barely detectable in non-tumor areas of both control and IL-21-deficient Apcmin/+ mice (Suppl. This evidence concerns the gene NFKB1 and neoplasm.