MT-ND2 and cancer: Further analysis of the downregulated genes in Nd2-mutant fibroblasts with DAVID Bioinformatics Resources 6.7 program [http://david.abcc.ncifcrf.gov/] revealed an enrichment of pathways mainly involved in cancer (fold enrichment 2.34) and MAPK signaling (fold enrichment 2.24) (Figure 4B).