Interestingly, other members of the sirtuin family are linked to ROS generation [35]; sirtuin 2 overexpression induced ROS generation in non-small-cell lung cancer [36], and sirtuin 2 was reported to induce alveolar mitochondrial biogenesis in the animal model of Staphylococcus aureus pneumonia [37]. Here, SIRT2 is linked to non-small cell lung carcinoma.