Here, we take advantage of MYC- [1], IL6- [2] and IL6MYC-transgenic (Tg) mice [3,4] that recapitulate important features of human Burkitt lymphoma (BL) or multiple myeloma (MM) to uncover up-regulated candidate cancer genes that might have been overlooked in other studies. The gene discussed is IL6; the disease is Burkitt lymphoma.