Because NF-κB and STAT3 are important regulators of B-lineage neoplasms in humans and mice, we used EMSA to examine NF-κB and STAT3 activity in MACS-purified B220+ samples from 19 primary tumors obtained from single-transgenic IL-6 (n = 6) or MYC (n = 5) mice and double-transgenic IL6MYC (n = 8) mice (Figure 1). This evidence concerns the gene MYC and neoplasm.