The mean FANCD2 mRNA level in myeloma cells (351 ± 268, n = 351) was 4.3-fold higher than in normal plasma cells (NPCs) from the bone marrow (81.2 ± 54.1, n = 22) and 1.8-fold higher than in plasma cells from individuals with monoclonal gammopathy of undetermined significance (MGUS; 195 ± 207, n = 44). This evidence concerns the gene FANCD2 and plasma cell myeloma.