In particular, Th2-type cell-specific chemokines, such as regulated on activation, normal T-cell expressed and secreted (RANTES/CCL5), thymus- and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22), are produced from keratinocytes, and may be effective targets for the treatment of inflammatory skin diseases [6]. This evidence concerns the gene CCL22 and inflammatory skin disease.