However, a number of studies determined that IL-17 inhibition does not prevent but rather only ameliorates the development of EAE [3, 4, 68, 69], CIA [70], SKG-arthritis, or SKG-ILD [63] and that neutralizing IL-17 is a rather unsatisfactory method for blocking Th17 mediated diseases [71, 72]. The gene discussed is IL17A; the disease is arthritic joint disease.