In a study in healthy volunteers, Pluta and colleagues reported that sustained infusion (several hours) of doses of ≈5 μg/kg/min sodium nitrite resulted in significant hypotension and methemoglobin >5%.15 Further studies are therefore warranted to evaluate whether sustained infusion of lower doses of NaNO2 would have similar favorable hemodynamic effects to those observed with short-term infusion of 50 μg/kg/min without inducing methemoglobinemia or resulting in hypotension. The gene discussed is HBG2; the disease is methemoglobinemia.