Therefore, we further evaluate the association between these 3 widely studied CAT gene polymorphisms (rs1001179, rs769217, and rs7943316) and the risk of hepatitis B virus (HBV)-related HCC in addition to chronic hepatitis B (CHB) and HBV-liver cirrhosis (LC) in the Guangxi Chinese population. The gene discussed is CAT; the disease is chronic hepatitis B virus infection.