The stratification of our population by age indicated that younger (<50 years) subjects carrying the rs769217 TT genotype and at least 1 copy of the T allele (dominant model) had a significantly increased risk of HCC relative to the CC genotype, with adjusted ORs of 2.19 (95% CI = 1.05–4.58) and 1.88 (95% CI = 1.08–3.28), respectively (see Table 2, Supplemental Content, http://links.lww.com/MD/A235, which illustrates the genotype distributions of CAT polymorphisms estimated by age). The gene discussed is CAT; the disease is hepatocellular carcinoma.