In addition to Aβ-induced synaptotoxicity, AD is characterized by the formation of neurofibrillary tangles and tau hyperphosphorylation.58 Aβ-induced tau phosphorylation4, 13, 41 has been proposed to be an early event leading to the formation of neurofibrillary tangles typical of tauopathy.41 In line with familial AD patient-derived iPSC-derived neurons,33 our data demonstrate that Aβ-induced tau phosphorylation occurs in hiPSC-derived neurons after short-term application of Aβ. Here, MAPT is linked to Alzheimer disease.