We did not have enough tumor material after protein analyses to perform human-specific quantitative real-time PCR for the MDA-MB-231 treatment study; however, the specific detection of the mRNA cleavage products in both SUM-149 and MDA-MB-231 tumors from mice treated intravenously using the TBG-siCDK11 and TBG-siCK2 nanocapsules, respectively, suggests that the appropriate transcripts are targeted for reduction. The gene discussed is SERPINA7; the disease is neoplasm.