Based on this finding, we can speculate that the lower expression of CD127 on the CD4+T cells may be caused by the higher levels of proinflammatory cytokines in much more severe HFRS patients, because that the significant higher levels of IL-6 and IL-8 have been observed in more severe patients than in milder HFRS cases [72]. This evidence concerns the gene CXCL8 and hemorrhagic fever with renal syndrome.