Thus, when we analyzed the relationship of the proliferation between HTNV-Gn/Gc-specific CD4+ and CD8+T cells, both the percentage and the MFI of the CFSEdim cells showed an expected positive correlations between CD4+ and CD8+T cells at the initial phase of infection in HFRS patients (Fig 7F-7G; P<0.0001, r = 0.8789 for MFI and P = 0.0002, r = 0.6051 for percentage). Here, CD4 is linked to hemorrhagic fever with renal syndrome.