CHAT and myeloid sarcoma: Thus, we speculate that BuChE, together with a soluble form of the ACh-synthesizing enzyme ChAT is involved in the regulation of extracellular ACh signaling, apart from cholinergic neurotransmission, and thereby regulates the functional status of various cholinoceptive, non-excitable cells, such as astrocytes, microglia and oligodendrocytes; all of which should be of high relevance to MS in context of inflammatory processes in the CNS [34, 59, 60].