PLPP3 and coronary artery disorder: Given the influence of the CAD risk variant rs72664324 on PPAP2B expression in the macrophage response to oxLDL and our observation that PPAP2B was the seventh most up-regulated gene in response to oxLDL exposure (Table 1), we studied the effects of oxLDL on the activity of the resulting protein product LPP3, and the expression pattern of LPP3 in atherosclerotic lesions.