At both loci the CAD-associated variants (rs7549338 and rs7553796 at IL6R; rs72664324 at PPAP2B) overlap single dynamic sites that had increased signals after oxLDL exposure; further, both IL6R and PPAP2B had significantly up-regulated expression in response to oxLDL (S4 Fig). This evidence concerns the gene PLPP3 and coronary artery disorder.