In spite of its initial characterization in the cancer biology field, our group have provided robust experimental evidence that TRAIL can drive prosurvival and/or proliferative effects and can modulate differentiation in normal cell types such as human intestinal cells [8], bone marrow multipotent stromal cells [9], myeloid cells [10–12], and osteoclastic cells [13, 14]. Here, TNFSF10 is linked to cancer.