Moreover, different studies have shown that sensitivity to TRAIL-induced apoptosis of cultured melanoma cells may be restored/enhanced by exposure to 2-deoxy-D-glucose (2-DG) [41, 42], aminooxyacetate (AOA), an inhibitor of glutamate-dependent transaminase [43], or cyclolignan picropodophyllin (PPP), a specific inhibitor of IGF-1R kinase activity [44]. Here, TNFSF10 is linked to melanoma.