Kommineni et al. reported 60.46% of head and neck squamous cell carcinoma (HNSCC) patients and 26% of controls with the following mutations 1634A>C (E545A) and 3075C>T (T1025T) in the helical and kinase domains of PIK3CA [25]. The gene discussed is PIK3CA; the disease is head and neck squamous cell carcinoma.