PDK4 and familial dilated cardiomyopathy: As outlined below, to date mutations in only two genes (PDK4 and STRN) and a single nucleotide polymorphism (SNP) on chromosome 5 have been associated with canine DCM (Mausberg et al., 2011; Meurs et al., 2012; Meurs et al., 2013), suggesting additional genetic causes remain unknown.