It was also concluded that ovariectomized females (or postmenopausal) after being diabetic suffer from more serious disturbances in lipid and carbohydrate metabolism, suggested by exacerbation of insulin resistance state in terms of disrupted lipid profile, higher HOMA-IR, hyperinsulinemia, higher leptin, and lower adiponectin concentrations. This evidence concerns the gene LEP and hyperinsulinism.