Even though using α-blockers or inhibiting epinephrine release by adrenal medullectomy improved glucose tolerance [299,300] and phentolamine treatment additionally prevented impairments in insulin secretion induced in mice by IH [299], the impact of IH on insulin sensitivity seems to be independent of autonomic activity as neither medullectomy, phentolamine treatment or administration of SNS blocking agent hexamethonium improved IH-induced insulin resistance in mice [252,299,300]. The gene discussed is INS; the disease is Insulin resistance.