PTTG1 and thyroid cancer: Kim et al. reported that knockout of the pituitary tumor-transforming gene (PTTG), which is associated with tumorigenesis, decreases proliferation, vascular invasion, and proangiogenic factors, including fibroblast growth factor (FGF2) and its receptor FGFR1 and VEGF, in mouse thyroid cancer with PTTG overexpression [12].