Nrf2−/− mice were generated in 1997 on the ICR mouse strain background [24] and then backcrossed to C57BL/6 strain for at least 6 generations [25]. Hmox1−/− mice show impaired regeneration in response to the hind limb ischemia [26] while Nrf2−/− mice show better revascularization due to the inflammatory angiogenesis [27]. Here, NFE2L2 is linked to ischemia.