Decreasing survivin expression using an antisense oligonucleotide (Supplementary Fig S10D) partially reversed CAF-CM-induced chemoprotection in gemcitabine-treated pancreatic cancer cells (Supplementary Fig S10E–F), demonstrating that CAF-CM-induced expression of survivin represents one effector of CAF-promoted chemoresistance. This evidence concerns the gene BIRC5 and familial pancreatic carcinoma.