Various apoptosis assays (caspase-3 and PARP cleavage, Fig1F and S2G–H; apoptotic annexin V-positive cells, Fig1G; executioner caspase activity, Supplementary Fig S3A) confirmed the cytotoxic action of chemotherapies on pancreatic cancer Panc-1 cells, which was abolished upon Panc-1 co-treatment with CM from CAFs, but restored when CM from CAFs treated with SOM230 was used. Here, ANXA5 is linked to familial pancreatic carcinoma.