CD40 and neoplasm: Therapeutic strategies aimed at symptomatically targeting the PDAC pro-tumoural fibrotic scaffold using non-selective enzymes that degrade it (Provenzano et al, 2012; Jacobetz et al, 2013), CD-40-educated macrophages that alter tumour stroma (Beatty et al, 2011), or nanoparticle albumin-bound chemotherapy (Von Hoff et al, 2011), showed promising results in pre-clinical models because they led to better chemotherapy delivery and uptake through stromal depletion and enhanced vascularization (Heinemann et al, 2014).