These data confirm that IL-6 is over-expressed and secreted by human intra-tumour CAFs during the process of pancreatic carcinogenesis, and that IL-6 secretion by CAFs is dramatically reduced by SOM230, thus providing a mechanism for SOM230 re-sensitization of pancreatic cancer cells towards gemcitabine cytotoxicity in vivo. Here, IL6 is linked to pancreatic neoplasm.