Coherent with our in vitro data, GLUT-1 immunoexpression in HCC cells was lower from the PIM1 knockdown clones in both subcutaneous inoculation (SMMC-7721) and orthotopic implantation (MHCC-97L) in mice when compared with NTC (Figures 5D & E). Here, PIM1 is linked to hepatocellular carcinoma.