BRCA2 (breast cancer type 2 susceptibility protein), probably with the help of BRCA1 (breast cancer type 1 susceptibility protein) and PALB2 (partner and localizer of BRCA2), promotes the loading of RAD51 onto RPA-coated ssDNA, which then enables strand invasion of a homologous DNA sequence in a sister chromatid and formation of a complex DNA arrangement that is resolved by mechanisms that may or may not result in crossover of the two DNA molecules [80]. Here, BRCA2 is linked to cancer.