Among the selectins, P-selectin contributes to disease pathology in many experimental models including myocardial and renal infarction, thrombosis, stroke, atherosclerosis, cerebral malaria and sickle cell disease19, as has been shown using P-selectin-blocking antibodies and knockout strategies in mouse, feline and baboon models20, 21, 22, 23. This evidence concerns the gene SELP and atherosclerosis.