As shown in Fig. 7, NF-κB-p65 staining was mainly located in cytoplasm with a weak staining in nuclei in most of CCM-treated control cells, whereas most of nuclei showed a strong NF-κB-p65 staining in albumin + CCM-treated cells, indicating a nuclear translocation of NF-κB. The gene discussed is NFKB1; the disease is cerebral cavernous malformation.