TGFB1 and neoplasm: TGF-β, however, may also be derived from tumor stroma cells [19, 38], where it shapes the microenvironment by interacting with growth factors (epidermal growth factor (EGF), platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), hepatocyte growth factor (HGF), insulin-like growth factor (IGF) [39]), cytokines or chemokines, crosstalking to fibroblasts [40] and supporting the enrichment of endothelial cells, which again shape the extracellular matrix [41].