ESR1 and breast carcinoma: This observation was endorsed by complementary analyses in breast cancer tissue; specifically, loss of cell polarity was revealed in in situ breast tissue lesions of BRCA1 mutation carriers and, accordingly, increased staining of phospho-T703-RHAMM (target of AURKA) was preferentially detected in estrogen receptor α (ERα)-negative and BRCA1-mutated tumors [4].