BRCA2 and breast cancer: Among these variants, the strongest evidence of association with breast cancer risk in BRCA1 mutation carriers was observed for the originally reported SNP rs299290 [4] (MAF = 0.25): BRCA1 per-allele HR = 1.10, 95% CI 1.04–1.15, p = 1.9 x 10−4 (FDR-adjusted p = 0.043, accounting for 41 genotyped SNPs used in the association analyses in BRCA1 and BRCA2 mutation carriers).