STC2 and breast cancer: To investigate the function of STC2 in breast cancer cells, we chose two breast cancer cell lines, MDA-MB-231 for overexpression of STC2, and MDA-MB-231 HM for silencing of STC2, because we had confirmed by q-PCR that MDA-MB-231(231) cells had low STC2 expression, whereas MDA-MB-231 HM (231 HM) cells had moderate expression of STC2 (data not shown).