In the CYP-induce cystitis animal model, we found that autophagic activity was reduced, but the presence of inflammatory factors (lL-1β, IL-6, IL-8) and oxidative stress markers MDA reached peak levels and nonenzymic antioxidant GSH and antioxidant enzymes SOD2 was reduced at 4 h after CYP injection. Here, SOD2 is linked to chronic cystitis.