NADH dehydrogenase 1 alpha subcomplex, 4-like 2 (NDUFA4L2, Gene ID: 56901; mRNA increased >50-fold in both TRACK kidneys and ccRCC) is a subunit of complex 1 in the electron transport chain; upregulated by HIF1α, it inhibits oxidative phosphorylation and thus promotes the shift in metabolism to glycolysis [34]. This evidence concerns the gene HIF1A and nonpapillary renal cell carcinoma.