These results strongly suggest that an anti-inflammatory response is responsible for the observed reduction in plaque size, they do not discriminate the reductions attributed to either of the anti-inflammatory cytokines, as both IL-10 and TGF-β, the two major cytokine products of Treg, have been implicated in playing a role in atherosclerosis [29,30]. The gene discussed is TGFB1; the disease is atherosclerosis.