FOXP3 and acute coronary syndrome: Clinical data showed that Th17/Treg functional imbalance exists in patients with acute coronary syndrome (ACS), a significant decrease in Treg number, Treg-related cytokines (IL-10 and TGF-β1), and Foxp3 levels, suggesting a potential role for Th17/Treg imbalance in plaque destabilization and the onset of ACS [39].