Murine renal fibroblast proliferation and kidney fibrosis following ureteric obstruction were significantly attenuated by KCa3.1 blockers [37], while in a streptazocin mouse model of diabetes-induced renal fibrosis, KCa3.1 inhibition reduced TGFβ1, TGFBRII and phosphoSmad2/3 expression in the tissue [34,38]. The gene discussed is TGFB1; the disease is Ureteral obstruction.