Surprisingly, we found an increase in IFN-γ levels over the 12 weeks in both Responders and Non-Responders, a finding that appears counterintuitive, since a recent meta-analysis report that antipsychotic treatment decreases this particular proinflammatory cytokine in patients.49 However, all of these studies assessed patients after a shorter interval (4–8 weeks), and it is possible that slightly longer treatment with atypical antipsychotics tends to induce production of cytokines through their propensity to generate metabolic syndrome.23 This evidence concerns the gene IFNG and metabolic syndrome.