Finally, it is interesting to note that the TP53INP1 paralog TP53INP2 (also known as DOR for diabetes and obesity related) is also involved in MS through its implication in autophagy (Nowak et al, 2009; Mauvezin et al, 2010; Sala et al, 2014). This evidence concerns the gene TP53INP2 and obesity due to melanocortin 4 receptor deficiency.