As susceptibility to obesity and T2D in TP53INP1-deficient mice is redox-linked, we addressed the question of the cellular origin of chronic oxidative stress in these mice (Gommeaux et al, 2007; Cano et al, 2009; N'Guessan et al, 2011). Here, TP53INP1 is linked to obesity due to melanocortin 4 receptor deficiency.