Except for OSM, the expression of all anti-tumor genes including TNF-α, PRF1, GZMB, FasL, TNFSF10 and CD40LG were significantly upregulated in CIK cells compared to PBMC, which were negatively correlated with expression profiles of their potential regulators (Figure 5B, Figure 6A and Figure 6B). Here, PRF1 is linked to neoplasm.