In multivariate analyses, variables associated with D1L were: LVL [OR: 1.88(95%CI: 1.04–3.38); p = 0.035], HIV co-infection [OR: 0.49 (95%CI:0.27–0.88); p = 0.016], IL28B-CC [OR: 8.75 (95%CI: 3.78–20.25); p< 0.001], Genotype 1 [OR: 1.93 (95%CI: 0.99–3.74); p = 0.05],Forns’ Index [OR: 0.73 (95%CI: 0.62–0.85); p < 0.001](Table 4). Here, IFNL3 is linked to coinfection.