IFNL3 and coinfection: Multivariateanalyses demonstrated that HIV co-infection, Forns’ index, LVL,IL28B-CC and Genotype-1 were independently related to RVR as well as D1L.Diagnostic accuracy (AUROC) for D1L was: 0.81 (95%CI: 0.76 — 0.86) inthe estimation cohort and 0.71 (95%CI: 0.62 — 0.79) in the validationcohort; RVR prediction: AUROC 0.83 (95%CI: 0.78 — 0.88) in theestimation cohort and 0.82 (95%CI: 0.76 — 0.88) in the validationcohort.