Remarkably, dysfunction of [K+]o regulation by Kir4.1 channels is likely involved in other pathologies, since it contributed to neuronal dysfunction in a mouse model of Huntington’s disease [50] and the presence of antibodies against Kir4.1 channels in glial cells was recently found in almost 50% of multiple sclerosis patients [51]. Here, KCNJ10 is linked to Huntington disease.