INS and diabetes mellitus: Furthermore, Table 1 indicated that diabetes produced disturbance of glucose homeostasis and insulin sensitivity manifested by significant elevation of fasting glucose, fasting insulin and HOMA IR index (F(1,40) = 111.19, P<0.0001; F(1,40) = 26.61, P<0.0001; F(1,40) = 4.27, P<0.05 respectively).