Fluoxetine significantly reversed CRS-induced changes in glucose homeostasis (F(3,40) = 13.89, P<0.0001; F(3,40) = 151.41, P<0.0001; F(3,40) = 86.53, P<0.0001 respectively), while imipramine exaggerated insulin resistance in non-diabetic rats as indicated by increased fasting insulin and HOMA IR index (P<0.001) compared to vehicle-treated groups. Here, INS is linked to Insulin resistance.