Baseline CD4 count, hepatitis B status, race, smoking status, AIDS ever or in the 12 mo prior to baseline, prior use of other antiretrovirals (including abacavir or indinavir), anaemia, and viral load (as either a continuous or categorical variable) were not significantly related to CKD after adjustment for the other variables listed and were excluded from our risk score models. The gene discussed is CD4; the disease is anemia (phenotype).