MX1 and hepatocellular carcinoma: It was previously shown that ISG proteins are poorly or not induced in HCV-infected hepatoma Huh-7 cells after rIFN-β treatment, despite efficient stimulation at the transcriptional level.[44] As seen in Fig. 4B (panels a-b), alfa and Lambda treatments induced the expression of Mx1 protein to similar degrees in naive iHLCs.