AFP and hepatocellular carcinoma: After adjusting for gender, age, HBsAg status, AFP level, TNM stage and differentiation, our data showed that SNPs rs7211875 and rs11871275 in ACACA gene were significantly associated with the death risk of HCC patients under recessive model (for rs7211875, HR = 2.13, 95% CI = 1.17–3.88; P = 0.01; for rs11871275, HR = 0.22, 95% CI = 0.06–0.91; P = 0.04).