APOE and atherosclerosis: In an attempt to examine some of the functions of macrophage α7nAChR that might be of relevance to atherosclerosis Wilund et al. [11] studied peritoneal macrophages derived from ApoE knockout mice with global deficiency of α7nAChR and found that these cells exhibited increased cholesterol accumulation and oxidized LDL uptake compared to control cells [11].